Basic Information
| LncRNA/CircRNA Name | TPM1-AS |
| Synonyms | NA |
| Region | GRCh38_15:63046034-63049387 |
| Ensemble | ENSG00000259498 |
| Refseq | NR_147233 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | RIP, qPCR, Western blot |
| Sample | cell lines (KYSE140, KYSE150, KYSE180, KYSE450 ,KYSE510, SHEEC) |
| Expression Pattern | up-regulated |
| Function Description | TPM1-AS overexpression or RBM4 knockdown decreased endogenous exon 2a expression of TPM1, resulting in specifically down-regulation of TPM1variant V2 and V7 in human esophageal cancer cells. overexpression of TPM1-AS inhibited migration and filopodium formation, whereas TPM1variant V2 and V7 promoted these behaviors of human esophageal cancer cells. |
| Pubmed ID | 28754317 |
| Year | 2017 |
| Title | Natural antisense transcript TPM1-AS regulates the alternative splicing of tropomyosin I through an interaction with RNA-binding motif protein 4. |
External Links
| Links for TPM1-AS | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |