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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	gastric cancer
ICD-0-3	C16
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown
Sample	gastric cancer tissues, cell lines (HT29, HCT116, SW480, SW620, and LoVo)
Expression Pattern	up-regulated
Function Description	The expression of CASC15 was upregulated in colon cancer tissues and its expression was correlated with clinical Tumor-Node-Metastasis stage and tumor metastasis. In addition, knockdown of CASC15 significantly inhibited the proliferation, migration and invasion of colon cancer cells in vitro and in vivo. Following mechanistic experiments, CASC15 was observed to act as a sponge to suppress microRNA (miR)-4310 that targeted LGR5. Through the inhibition of miR-4310, CASC15 promoted leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) expression and consequently activated the Wnt/?-catenin signaling pathway. The results revealed that the inhibition of the Wnt/?-catenin signaling pathway in CASC15-overexpressing colon cancer cells suppressed cellular proliferation, migration and invasion. Collectively, these results demonstrated that CASC15 promoted colon cancer growth and metastasis through the activation of the Wnt/?-catenin signaling pathway in a miR-4310/LGR5 dependent manner.
Pubmed ID	29956772
Year	2018
Title	LncRNA CASC15 Promotes Colon Cancer Cell Proliferation and Metastasis by Regulating the miR-4310/LGR5/Wnt/?-catenin Signaling Pathway

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