Basic Information
| LncRNA/CircRNA Name | CASC15 |
| Synonyms | NA |
| Region | GRCh38_6:21664772-22368328 |
| Ensemble | ENSG00000272168 |
| Refseq | NR_015410 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | melanoma tissues, cell lines(A375, SK-MEL-2, M21, MEL-RM, B16, and SK-MEL-1) |
| Expression Pattern | up-regulated |
| Function Description | We found that CASC15 expression was up-regulated in melanoma tissues and associated with advanced pathological stages. Function experiments displayed that CASC15 knockdown hindered proliferation, facilitated apoptosis and suppressed invasion, while CASC15 overexpression facilitated proliferation and invasion in melanoma cells. Further mechanistic analysis showed that CASC15 epigenetically silenced the expression of programmed cell death 4 (PDCD4) by recruiting EZH2 and increasing H3K27me3 level at the promoter region of PDCD4. Additionally, PDCD4 overexpression inhibited proliferation, enhanced apoptosis and decreased invasion of melanoma cells. Moreover, CASC15-knockdown-induced anti-cancer effects were abated by PDCD4 down-regulation. Furthermore, depletion of CASC15 blocked tumor growth of melanoma by up-regulating PDCD4 in vivo. |
| Pubmed ID | 30013768 |
| Year | 2018 |
| Title | Long Non-Coding RNA CASC15 Promotes Melanoma Progression by Epigenetically Regulating PDCD4 |
External Links
| Links for CASC15 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |