Basic Information
| LncRNA/CircRNA Name | TP73-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000227372 |
| Refseq | NR_033708 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | RT-PCR, Western blotting, in vitro knockdown etc. |
| Sample | EOC tumor tissues, Epithelial ovarian cancer cell lines (SKOV3, CAOV3, HO8910, OV420) and normal human ovarian epithelial cell line (HOSEPiC) |
| Expression Pattern | up-regulated |
| Function Description | In the EOC specimens and cell lines, TP73-AS1 was identified to be significantly up-regulated. EOC patients with high TP73-AS1 expression had poor survival rate. TP73-AS1 promoted the proliferation, invasion and reduced the apoptosis of EOC cells in vitro.And, the knockdown of TP73-AS1 inhibited the tumor growth in vivo. TP73-AS1 epigenetically repressed p21 via recruiting EZH2. |
| Pubmed ID | 31105851 |
| Year | 2019 |
| Title | Long noncoding RNA TP73-AS1 accelerates the epithelial ovarian cancer via epigenetically repressing p21 |
External Links
| Links for TP73-AS1 | GenBank HGNC NONCODE |
| Links for epithelial ovarian cancer | OMIM COSMIC |