Basic Information
| LncRNA/CircRNA Name | TP73-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000227372 |
| Refseq | NR_033708 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RT-qPCR, Western blotting |
| Sample | CRC tissues,CRC cell lines CR4 (Sigma-Aldrich, USA) and RKO (ATCC, USA), as well as normal colon cell line CCD-18Co |
| Expression Pattern | up-regulated |
| Function Description | TP73-AS1 was upregulated in CRC tissues compared with adjacent non-CRC tissues in CRC patients. Upregulation of TP73-AS1 was closely correlated with poor prognosis. TGF-?1 was also upregulated in CRC tissues and positive correlated with TP73-AS1. TP73-AS1 overexpression caused upregulated TGF-?1 in CRC cells, while TGF-?1 overexpression showed no significant effect on TP73-AS1. TP73-AS1 and TGF-?1 overexpressions caused enhanced migration and invasion of CRC cells. |
| Pubmed ID | 31908524 |
| Year | 2019 |
| Title | LncRNA TP73-AS1 Activates TGF-?1 to Promote the Migration and Invasion of Colorectal Cancer Cell |
External Links
| Links for TP73-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |