Basic Information
| LncRNA/CircRNA Name | CASC11 |
| Synonyms | CASC11, CARLo-7, LINC00990, TCONS_00014535 |
| Region | GRCh38_8:127686343-127733967 |
| Ensemble | ENSG00000249375 |
| Refseq | NR_117101 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, RIP, Luciferase reporter assay, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | CRC tissues, cell lines (LoVo, RKO, SW620, HCT116, SW480 and LS174T) |
| Expression Pattern | up-regulated |
| Function Description | Here, we report that CASC11 was upregulated in CRC tissues; increased CASC11 expression in CRC was associated with tumor size, serosal invasion, lymph metastasis, and the TNM stage. Functional experiments showed that CASC11 can promote CRC cell proliferation and metastasis in vitro and in vivo. Furthermore, CASC11 can target heterogeneous ribonucleoprotein K (hnRNP-K) to activate WNT/B-catenin signaling in CRC cells. In addition, we found that c-Myc directly bound to the promoter regions of CASC11 and increased promoter histone acetylation to enhance CASC11 expression. |
| Pubmed ID | 27012187 |
| Year | 2016 |
| Title | Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/B-catenin pathway to promote growth and metastasis in colorectal cancer. |
External Links
| Links for CASC11 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |