Basic Information
| LncRNA/CircRNA Name | TP73-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000227372 |
| Refseq | NR_033708 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | osteosarcoma tissues, cell lines (Eca109, EC-1, EC9706, KYSE30 and KYSE150) |
| Expression Pattern | up-regulated |
| Function Description | High TP73-AS1 expression was associated with poor overall survival of OS patients. TP73-AS1 knockdown suppressed OS cells proliferation and invasion in vitro as well as tumor growth in vivo. LncRNA TP73-AS1 knockdown inhibits ESCC proliferation and induces apoptosis. Furthermore, we identified that miR-142 could act as a direct target for TP73-AS1 and miR-142 inhibition reversed the suppression of OS cells proliferation and invasion induced by TP73-AS1 knockdown. In addition, we showed that TP73-AS1 could function as a sponge of miR-142 to positively regulate Rac1 in OS cells. |
| Pubmed ID | 29864904 |
| Year | 2018 |
| Title | Knockdown of Long Non-Coding RNA TP73-AS1 Inhibits Osteosarcoma Cell Proliferation and Invasion Through Sponging miR-142 |
External Links
| Links for TP73-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |