Basic Information
| LncRNA/CircRNA Name | TP53TG1 |
| Synonyms | TP53TG1, LINC00096, NCRNA00096, P53TG1, P53TG1-D, TP53AP1 |
| Region | GRCh38_7:87325225-87345515 |
| Ensemble | ENSG00000182165 |
| Refseq | NR_015381 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | glioma tissues, cell lines (U251, U87, LN18, A172, NHA) |
| Expression Pattern | up-regulated |
| Function Description | The expression of TP53TG1 was significantly higher in human glioma tissues or cell lines compared with normal brain tissue or NHA. TP53TG1 and some tumor glucose metabolism related genes, such as GRP78, LDHA, and IDH1 were up-regulated significantly in U87 and LN18 cells under glucose deprivation. knockdown of TP53TG1 decreased cell proliferation and migration and down-regulated GRP78 and IDH1 expression levels and up-regulated PKM2 levels in U87 cells under glucose deprivation.the effects of TP53TG1 were more remarkable in low glucose than that in high glucose. |
| Pubmed ID | 28569381 |
| Year | 2017 |
| Title | LncRNA-TP53TG1 Participated in the Stress Response Under Glucose Deprivation in Glioma. |
External Links
| Links for TP53TG1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |