Basic Information
| LncRNA/CircRNA Name | TP53TG1 |
| Synonyms | TP53TG1, LINC00096, NCRNA00096, P53TG1, P53TG1-D, TP53AP1 |
| Region | GRCh38_7:87325225-87345515 |
| Ensemble | ENSG00000182165 |
| Refseq | NR_015381 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | Microarray, qPCR, RNA pull-down assay etc. |
| Sample | cell line (HCT-116) |
| Expression Pattern | down-regulated |
| Function Description | Herein, we have identified a p53-induced lncRNA, TP53TG1, that undergoes cancer-specific promoter hypermethylation-associated silencing. In vitro and in vivo assays identify a tumor-suppressor activity for TP53TG1 and a role in the p53 response to DNA damage. Importantly, we show that TP53TG1 binds to the multifaceted DNA/RNA binding protein YBX1 to prevent its nuclear localization and thus the YBX1-mediated activation of oncogenes. TP53TG1 epigenetic inactivation in cancer cells releases the transcriptional repression of YBX1-targeted growth-promoting genes and creates a chemoresistant tumor. |
| Pubmed ID | 27821766 |
| Year | 2016 |
| Title | Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer. |
External Links
| Links for TP53TG1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |