Basic Information
| LncRNA/CircRNA Name | TP53TG1 |
| Synonyms | NA |
| Region | GRCh38_7:87325225-87345515 |
| Ensemble | ENSG00000182165 |
| Refseq | NR_015381 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RNAi, RIP |
| Sample | The PDAC cell lines PANC-1 and MIA PaCa-2, BxPC-3 cells, PDAC tissues and matched adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | TP53TG1 was highly expressed in PDAC and was a novel regulator of PDAC development. Knockdown of TP53TG1 inhibited proliferation, induced apopto- sis, and decreased migration and invasion in PDAC cells, whereas enhanced expression of TP53TG1 had the opposite effects. Mechanistically, TP53TG1 could directly bind to microRNA (miR)-96 and effectively function as a sponge for miR-96, thus antagonizing the functions of miR-96 and leading to derepression of its endogenous target KRAS, which is a core oncogene in the initiation and maintenance of PDAC. |
| Pubmed ID | 31325400 |
| Year | 2019 |
| Title | Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA-96 |
External Links
| Links for TP53TG1 | GenBank HGNC NONCODE |
| Links for pancreatic ductal adenocarcinoma | OMIM COSMIC |