Basic Information
| LncRNA/CircRNA Name | CASC11 |
| Synonyms | NA |
| Region | GRCh38_8:127686343-127733967 |
| Ensemble | ENSG00000249375 |
| Refseq | NR_117101 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | Human foreskin keratinocytes (HEKn, Cat. no. C-001-5C), Te human cervical cancer cell lines (HeLa, CaSki, SiHa, C-33A and MS751) , Cancerous and adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | CASC11, the expression of which was positively associated with the tumor size and the FIGO staging and negatively related to the patients` survival rate, was up-regulated in the cervical cancer tissues and cell lines. Silencing CASC11 inhibited the proliferation, migration as well as invasion and promoted the cell apoptosis. Conversely, overexpression of CASC11 facilitated the cancer cell`s proliferation, migration and invasion ability and suppressed the apoptosis. Further study showed that CASC11 promoted the migration and invasion of cervical cancer cells by activating Wnt/?-catenin signaling pathway and silencing CASC11 inhibited the tumor growth in vivo. |
| Pubmed ID | 31255182 |
| Year | 2019 |
| Title | LncRNA CASC11 promotes the cervical cancer progression by activating Wnt/beta-catenin signaling pathway |
External Links
| Links for CASC11 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |