Basic Information
| LncRNA/CircRNA Name | TNRC6C-AS1 |
| Synonyms | NA |
| Region | GRCh38_17:78107398-78111799 |
| Ensemble | ENSG00000204282 |
| Refseq | NR_040071 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | iodine | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | mircoarray, qPCR, Western blot, Luciferase Reporter Assay |
| Sample | papillary thyroid cancer tissues, cell lines (TPC1, BCPAP, K1, Nthy-ori3-1) |
| Expression Pattern | up-regulated |
| Function Description | The expression of TNRC6C-AS1 was significantly higher, while the TNRC6C mRNA and protein were significantly lower in PTC tissues than normal adjacent tissues. Downregulation of TNRC6C-AS1 or overexpression of TNRC6C inhibited proliferation, migration and invasion of TPC1 cells, while apoptosis and iodine uptake was promoted in TPC1 cells. |
| Pubmed ID | 30038597 |
| Year | 2018 |
| Title | Long Non-coding Antisense RNA TNRC6C-AS1 Is Activated in Papillary Thyroid Cancer and Promotes Cancer Progression by Suppressing TNRC6C Expression. |
External Links
| Links for TNRC6C-AS1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |