Basic Information
| LncRNA/CircRNA Name | TMPO-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:98512973-98516422 |
| Ensemble | ENSG00000257167 |
| Refseq | NR_027157 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | cervical cancer tissues,cell lines (HeLa, SiHa, CaSki, C-33A) |
| Expression Pattern | up-regulated |
| Function Description | TMPO-AS1 was highly expressed in cervical cancer cells. Furthermore, TMPO-AS1 overexpression significantly promoted C-33A cell proliferation, migration, and invasion. In contrast, TMPO-AS1 silencing inhibited SiHa cell proliferation, migration, and invasion. Mechanistically, TMPO-AS1 acted as a sponge of miR-143-3p to elevate expression of zinc finger E-box binding homeobox 1 (ZEB1), a target of miR-143-3p, and thereby promoted C-33A cell proliferation, migration, and invasion. |
| Pubmed ID | 32184662 |
| Year | 2020 |
| Title | Long Non-Coding RNA TMPO-AS1 Promotes Cervical Cancer Cell Proliferation, Migration, and Invasion by Regulating miR-143-3p/ZEB1 Axis |
External Links
| Links for TMPO-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |