Basic Information
| LncRNA/CircRNA Name | TLR8-AS1 |
| Synonyms | NA |
| Region | GRCh38_X:12902817-12908333 |
| Ensemble | ENSG00000233338 |
| Refseq | NR_030727 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | ovarian cancer tissues,cell lines(OV90, SKOV3 ) |
| Expression Pattern | up-regulated |
| Function Description | TLR8-AS1 is positively associated with poor patient survival and TLR8 expression.Moreover, TLR8-AS1 upregulates TLR8 by stabilizing TLR8 mRNA, thus activating NF-kB signaling and promoting ovarian cancer metastasis and chemoresistance. |
| Pubmed ID | 32278547 |
| Year | 2020 |
| Title | LncRNA TLR8-AS1 promotes metastasis and chemoresistance of ovarian cancer through enhancing TLR8 mRNA stability. |
External Links
| Links for TLR8-AS1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |