Basic Information
| LncRNA/CircRNA Name | TINCR |
| Synonyms | TINCR, LINC00036, NCRNA00036, PLAC2, onco-lncRNA-16 |
| Region | GRCh38_19:5558167-5578349 |
| Ensemble | ENSG00000223573 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay, Luciferase reporter assay, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | CRC tissues, cell lines (FHC, LOVO, M5, HCT116, HT29, RKO, LS174T, SW480, SW620, and HEK294) |
| Expression Pattern | down-regulated |
| Function Description | TINCR was statistically downregulated in CRC tissues and metastatic CRC cell lines compared with their counterparts. TINCR was reversely correlated with CRC progression and promoted tumor cells growth, metastasis in vivo and in vitro. In addition, we also found that TINCR specifically bound to EpCAM through RNA IP and RNA pull down assays. Loss of TINCR promoted hydrolysis of EpCAM and then released EpICD, subsequently, activated the Wnt/B-catenin pathway. Further studies shown that c-Myc repressed the expression of TINCR through repressing sp1 transcriptive activity, which established a positive feedback loop controlling c-Myc and TINCR expression. |
| Pubmed ID | 27009809 |
| Year | 2016 |
| Title | Loss of TINCR expression promotes proliferation, metastasis through activating EpCAM cleavage in colorectal cancer. |
External Links
| Links for TINCR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |