Basic Information
| LncRNA/CircRNA Name | CASC11 |
| Synonyms | CASC11, CARLo-7, LINC00990, TCONS_00014535 |
| Region | GRCh38_8:127686343-127733967 |
| Ensemble | ENSG00000249375 |
| Refseq | NR_117101 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | GC tissues and cell lines (GES-1, MKN7) |
| Expression Pattern | up-regulated |
| Function Description | CASC11 was highly expressed in GC tissues and cell lines. Knockdown of CASC11 inhibited GC cell proliferation, promoted cell apoptosis and blocked cell cycle. KEGG further indicated an enriched cell cycle pathway involving CDK1. QRT-PCR showed that miR-340-5p was down-regulated in GC cells tissues, while CDK1 was up-regulated. Furthermore, CASC11 acted as a sponge of miR-340-5p which directly targeted CDK1. Meanwhile, miR-340-5p overexpression promoted GC cell apoptosis and induced cell cycle arrest, while CDK1 overexpression inhibited cell apoptosis and accelerated cell cycle. Our study revealed the mechanism of CASC11/miR-340-5p/CDK1 network in GC cell line, and suggested that CASC11 was a novel facilitator that exerted a biological effect by activating the cell cycle signaling pathway. |
| Pubmed ID | 30200804 |
| Year | 2018 |
| Title | LncRNA CASC11 Promoted Gastric Cancer Cell Proliferation, Migration and Invasion in Vitro by Regulating Cell Cycle Pathway |
External Links
| Links for CASC11 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |