Basic Information
| LncRNA/CircRNA Name | TINCR |
| Synonyms | TINCR, LINC00036, NCRNA00036, PLAC2, onco-lncRNA-16 |
| Region | GRCh38_19:5558167-5578349 |
| Ensemble | ENSG00000223573 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | CRC tissues, CRC cell lines HCT116 and SW620 and normal cell line CCD 841 CON |
| Expression Pattern | down-regulated |
| Function Description | The expression levels of the TINCR and CD36 were down-regulated. We identified miR-107 as an inhibitory target of TINCR and CD36. Overexpression of TINCR could inhibit cell proliferation and promote apoptosis. MiR-107 overexpression in CRC cells induced proliferation and impeded apoptosis. Regulatory function of lncRNA TINCR/miR-107/CD36 axis in CRC was revealed. LncRNA TINCR overexpression exerted suppressive influence on CRC progression through modulating PPAR signaling pathway via miR-107 / CD36 axis |
| Pubmed ID | 30521471 |
| Year | 2018 |
| Title | LncRNA TINCR / microRNA-107 / CD36 regulates cell proliferation and apoptosis in colorectal cancer via PPAR signaling pathway based on bioinformatics analysis |
External Links
| Links for TINCR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |