Basic Information
| LncRNA/CircRNA Name | TINCR |
| Synonyms | TINCR, LINC00036, NCRNA00036, PLAC2, onco-lncRNA-16 |
| Region | GRCh38_19:5558167-5578349 |
| Ensemble | ENSG00000223573 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot analysis |
| Sample | HCC tissues ,HCC cell lines H1581 and SNU-475 |
| Expression Pattern | up-regulated |
| Function Description | TINCR and ROCK1 were upregulated, while miR-214-5p was downregulated in HCC.TINCR and ROCK1 overexpression led to increased rate of cancer cell proliferation, while miR-214-5p played an opposite role and reduced the effects of TINCR overexpression. Therefore, TINCR sponges miR-214-5p to upregulate ROCK1 in HCC, thereby promoting cancer cell invasion and migration. |
| Pubmed ID | 31900116 |
| Year | 2020 |
| Title | lncRNA TINCR Sponges miR-214-5p to Upregulate ROCK1 in Hepatocellular Carcinoma |
External Links
| Links for TINCR | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |