Basic Information
| LncRNA/CircRNA Name | THUMPD3-AS1 |
| Synonyms | THUMPD3 antisense RNA 1 |
| Region | GRCh38_3:9349689-9398579 |
| Ensemble | ENSG00000206573 |
| Refseq | NR_027007 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-PCR, Dual Luciferase Reporter Assay, Western blotting |
| Sample | NSCLC epithelial cell lines (A549 and H1299 cells,NSCLC tissues |
| Expression Pattern | up-regulated |
| Function Description | Overexpression and knockdown analysis revealed that THUMPD3-AS1 promoted tumor progression by increasing cell proliferation and self-renewal of NSCLC cells. Moreover, THUMPD3-AS1 may act as an endogenous sponge of microRNA-543 (miR-543) which can regulate the target gene ONECUT2 in NSCLC cells. |
| Pubmed ID | 31819483 |
| Year | 2019 |
| Title | THUMPD3-AS1 Is Correlated With Non-Small Cell Lung Cancer And Regulates Self-Renewal Through miR-543 And ONECUT2 |
External Links
| Links for THUMPD3-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |