Basic Information
| LncRNA/CircRNA Name | CASC11 |
| Synonyms | NA |
| Region | GRCh38_8:127686343-127733967 |
| Ensemble | ENSG00000249375 |
| Refseq | NR_117101 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qRT-PCR, Western blot |
| Sample | ECa tissues,ECa cell lines (OE19, OE33, TE1, KYSE30, and EC-109) and one human normal esophageal epithelial cell line (HEEC) |
| Expression Pattern | up-regulated |
| Function Description | the expression level of lncRNA CASC11 in the ECa tissues was remarkably higher than that of the adjacent normal tissues.Compared with patients with a low level of lncRNA CASC11, the pathological stage of patients with high expression was significantly higher, while the overall survival rate was lower.Compared with negative control (NC) group, the proliferation ability of the cells in the lncRNA CASC11 knockdown group CASC11 significantly decreased, whereas cell apoptosis remarkably increased.protein expression of KLF6 was remarkably up-regulated after lncRNA CASC11 knockdown. |
| Pubmed ID | 31696474 |
| Year | 2019 |
| Title | LncRNA CASC11 Promotes the Development of Esophageal Carcinoma by Regulating KLF6 |
External Links
| Links for CASC11 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |