Basic Information
| LncRNA/CircRNA Name | TGLC15 |
| Synonyms | RP11-279F6.2 (ENSG00000259457) |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, in vitro knockdown, RIP, etc. |
| Sample | HCC tissues, cell lines HCC-LM3, 97L, Huh7, HepG2, Hep3B, and the normal L02 cell line |
| Expression Pattern | up-regulated |
| Function Description | TGLC15 is significantly overexpressed in tumor tissues and HCC cell lines. Higher TGLC15 levels correlated with advanced malignant characteristics such as TNM stages, tumor size, and metastasis. TGLC15 advanced HCC migration and vi ability. The in vivo experiments supported that xenograft tumor growth and pro liferation were facilitated by TGLC15 overexpression. Mechanistic studies showed that TGLC15 interacted with Sox4 and interaction between TGLC15 and Sox4 could stabilize Sox4 via reduction in proteasome mediated degradation. |
| Pubmed ID | 31495979 |
| Year | 2019 |
| Title | Long non-coding RNA TGLC15 advances hepatocellular carcinoma by stabilizing Sox4 |
External Links
| Links for TGLC15 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |