Basic Information
| LncRNA/CircRNA Name | TDRG1 |
| Synonyms | NA |
| Region | GRCh38_6:40334954-40379887 |
| Ensemble | ENSG00000204091 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | RT-PCR, Western blot, Luciferase reporter assay |
| Sample | EOC tissue, human ovarian carcinoma cell lines (OVCAR3 and A2780) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA TDRG1 (human testis development-related gene 1) was highly expressed in EOC tissues than in normal ovarian tissues, and expression differed significantly with differentiation. LncRNA TDRG1 downregulation suppressed EOC cell proliferation, migration, and invasion, while its overexpression had the opposite effect.LncRNA TDRG1 has possible miRNA-93 (miR-93) binding sites. LncRNA TDRG1 downregulation upregulated miR-93 expression, while its overexpression reduced miR-93 expression. |
| Pubmed ID | 28984384 |
| Year | 2017 |
| Title | The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway. |
External Links
| Links for TDRG1 | GenBank HGNC NONCODE |
| Links for epithelial ovarian cancer | OMIM COSMIC |