Basic Information
| LncRNA/CircRNA Name | TCONS_l2_00002973 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR , Western blot etc. |
| Sample | TNBC tissues and adjacent normal tissues ,breast cancer cell lines including BT474, MCF7,MDA-MB-453 and MDA-MB-231 ,normal breast epithelial cell line MCF10A |
| Expression Pattern | down-regulated |
| Function Description | LncRNA TCONS_l2_00002973 expression was lower in tumor tissue compared to paired adjacent tissue, and its low expression was associated with increased T stage , raised N stage and advanced TNM stage in TNBC patients.Poor OS was found in lncRNA TCONS_l2_00002973 low expression group compared to lncRNA TCONS_l2_00002973 high expression group.TCONS_l2_00002973 expression was reduced in various breast cancer cell lines compared to normal breast cell line, and lncRNA TCONS_l2_00002973 repressed cell proliferation and enhanced cells apoptosis in MDA-MB-231 cells. |
| Pubmed ID | 31128002 |
| Year | 2019 |
| Title | LncRNA TCONS_l2_00002973 Correlates With Less Advanced Tumor Stage and Favorable Survival, and Also Inhibits Cancer Cells Proliferation While Enhancing Apoptosis in Triple-Negative Breast Cancer |
External Links
| Links for TCONS_l2_00002973 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |