Basic Information
| LncRNA/CircRNA Name | TCL6 |
| Synonyms | TCL6, TNG1, TNG2 |
| Region | GRCh38_14:95650498-95679833 |
| Ensemble | ENSG00000187621 |
| Refseq | NR_028288 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute T-lymphocytic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | cell line (COS7) |
| Expression Pattern | up-regulated |
| Function Description | In tumor cells, a high level of expression was observed in a cell line of acute T-lymphocytic leukemia derived from patient NL. The TCL6 gene as well as TCL6-TML1 fusion transcripts are mainly expressed in the B-cell lineage and are not expressed in T-cells, and that it becomes deregulated as a consequence of its juxtaposition to the TCRA/D locus (just like the TCL1 oncogene and the candidate oncogene TML1). Although both the oncogenic potential of the TCL6 gene and the significance of the fusion transcripts coding for ORF72 remain to be determined, our results suggested that TCL6 is also a candidate gene potentially involved in leukemogenesis. |
| Pubmed ID | 10851082 |
| Year | 2000 |
| Title | Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. |
External Links
| Links for TCL6 | GenBank HGNC NONCODE |
| Links for acute T-lymphocytic leukemia | OMIM COSMIC |