Basic Information
| LncRNA/CircRNA Name | TCL6 |
| Synonyms | T-cell leukemia/lymphoma 6 |
| Region | GRCh38_14:95650498-95679833 |
| Ensemble | ENSG00000187621 |
| Refseq | NR_028288 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | RT-PCR, Luciferase reporter assay |
| Sample | Rb tissues,Rb cell lines, Y79 (ATCC HTB-18) and WERI-Rb-1 (ATCC HTB-169) |
| Expression Pattern | down-regulated |
| Function Description | the expression of lncRNA T-cell leukemia/lymphoma 6 (TCL6) was significantly downregulated in Rb tissues and cell lines. Knockdown of lncRNA TCL6 promoted cell proliferation while reduced cell apoptosis in Rb cells. Moreover, lncRNA TCL6 serves as a sponge for miR-21, a previously-reported oncogenic miRNA in Rb, by direct targeting to negatively regulated miR-21 expression, therefore modulating Rb proliferation through miR-21. |
| Pubmed ID | 31680766 |
| Year | 2019 |
| Title | Long Non-Coding RNA T-cell Leukemia/Lymphoma 6 Serves as a Sponge for miR-21 Modulating the Cell Proliferation of Retinoblastoma Through PTEN |
External Links
| Links for TCL6 | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |