Basic Information
| LncRNA/CircRNA Name | TCL6 |
| Synonyms | NA |
| Region | GRCh38_14:95650498-95679833 |
| Ensemble | ENSG00000187621 |
| Refseq | NR_028288 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | RT-PCR |
| Sample | RCC tissues,cell lines (OS-RC-2, KC, ACHN, 786-O, and Caki-1) |
| Expression Pattern | down-regulated |
| Function Description | TCL6 effectively sensitizes RCC to PTX mainly through downregulation of miR-221. |
| Pubmed ID | 32047545 |
| Year | 2020 |
| Title | Long non-coding RNA TCL6 enhances preferential toxicity of paclitaxel to renal cell carcinoma cells |
External Links
| Links for TCL6 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |