Detail

Basic Information

LncRNA/CircRNA Name	T-ALL-R-lncR1
Synonyms	NA
Region	NA
Ensemble	NA
Refseq	NA

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	acute lymphoblastic leukemia
ICD-0-3	NA
Methods	qPCR, RNAi, Western blot etc.
Sample	T-ALL jurkat cell
Expression Pattern	up-regulated
Function Description	T-ALL-R-LncR1 was not observed in human normal tissues. However, an obvious expression was observed in some tumor tissues. T-ALL-R-LncR1 was markedly expressed in neoplastic T lymphocytes of 11 cases out of 21 children with T-ALL, indicating that T-ALL-R-LncR1 might be associated with T-ALL. T-ALL-R-LncR1 knockdown predisposed Jurkat cells to undergo pro-apoptotic factor Par-4-induced apoptosis. Further studies revealed that T-ALL-R-LncR1 knockdown facilitated the formation of a Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells
Pubmed ID	23906015
Year	2014
Title	A novel long non-coding RNA T-ALL-R-LncR1 knockdown and Par-4 cooperate to induce cellular apoptosis in T-cell acute lymphoblastic leukemia cells

External Links

Links for T-ALL-R-lncR1	GenBank HGNC NONCODE
Links for acute lymphoblastic leukemia	OMIM COSMIC