Basic Information
| LncRNA/CircRNA Name | SYNPR-AS1 |
| Synonyms | NA |
| Region | GRCh38_3:63423596-63550051 |
| Ensemble | ENSG00000241359 |
| Refseq | NR_046677 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR |
| Sample | Human non-tumor lung epithelial BEAS-2B cells, 293 cells, NSCLC A549, NCI-H460, NCI-H1299 and NCI-H292 cells, NSCLC and non-tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | LINC00525, MED4-AS1, STEAP2-AS1 and SYNPR-AS1 lncRNAs were selected and validated for their association with the survival of NSCLC patients. The expression of these lncRNAs was upregulated in 48 NSCLC tissues and was varying in NSCLC cells. While LINC00525 was mainly expressed in the cytoplasm, MED4-AS1 was in both the nucleus and cytoplasm of A549 cells. In addition, the expression of LINC00525 was significantly associated with smoking history (P<0.05); MED4-AS1 was significantly associated with women, poor differentiation and lymph node metastasis (P<0.05); STEAP2-AS1 was significantly associ- ated with women (P<0.01); and SYNPR-AS1 was significantly associated with women and adenocarcinoma (P<0.05). |
| Pubmed ID | 31638253 |
| Year | 2019 |
| Title | Integrated analysis highlights multiple long non-coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma |
External Links
| Links for SYNPR-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |