Basic Information
| LncRNA/CircRNA Name | SUMO1P3 |
| Synonyms | NA |
| Region | GRCh38_1:160317403-160317706 |
| Ensemble | ENSG00000235082 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | imatinib | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assay |
| Sample | breast cancer tissues, cell lines (MCF-10A, MCF7, MDA-MB-231, MDA-MB-468, and SKBR-3) |
| Expression Pattern | up-regulated |
| Function Description | high levels of SUMO1P3 expression associated significantly with tumor progression and poor survival of breast cancer patients.knockdown of SUMO1P3 suppressed proliferation, migration, and invasion of breast cancer cells. SUMO1P3 binds to miR-320a,which has been identified as a tumor suppressor in various cancers, including breast cancer. the tumor-promoting effects of SUMO1P3 in breast cancer are partly mediated by negative regulation of miR-320a. |
| Pubmed ID | 29312511 |
| Year | 2017 |
| Title | The long non-coding RNA SUMO1P3 facilitates breast cancer progression by negatively regulating miR-320a. |
External Links
| Links for SUMO1P3 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |