Basic Information
| LncRNA/CircRNA Name | STCAT3 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP, RNAi, other |
| Sample | GC tissues and cell lines (AGS,MGC-803, BGC-823, MKN-28, MKN-45 and SGC-7901) |
| Expression Pattern | up-regulated |
| Function Description | Finally, dermcidin was identified as the binding protein of STCAT3 by comparing the mRNA and protein levels of the candidate genes and their correlations with STCAT3 in plasmid-transfected BGC-823 GC cell lines, as well as by validating the interplay between dermcidin and STCAT3 in other GC cell lines. Immunohistochemical analysis of tissues from 98 patients with GC further confirmed the interaction between dermcidin and STCAT3. The results of the present study also revealed that STCAT3 and dermcidin and independent predictors of overall survival in patients with GC. Furthermore STCAT3 and dermcidin are positively correlated with lymph node metastasis and tumor/node/metastasis score. |
| Pubmed ID | 30226544 |
| Year | 2018 |
| Title | Dermcidin as a Novel Binding Protein of lncRNA STCAT3 and Its Effect on Prognosis in Gastric Cancer |
External Links
| Links for STCAT3 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |