Basic Information
| LncRNA/CircRNA Name | CAR10 |
| Synonyms | ADAM12, ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA |
| Region | GRCh38_10:126012381-126388455 |
| Ensemble | ENSG00000148848 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | LUAD tissue, NCI-H358, A549, PC9, B16, AGS, MCF7, HeLa, HepG2, SW480, BESA-2B cells, HEK293, HEK293T, and the normal human bronchial epithelial cell line (HBE) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA chromatin-associated RNA 10 (CAR10) was upregulated in the tumor tissue of patients with LUAD and enhanced tumor metastasis in vitro and in vivo. Mechanistically, CAR10 induced epithelial-to-mesenchymal transition (EMT) by directly binding with miR-30 and miR-203 and then regulating the expression of SNAI1 and SNAI2. CAR10 overexpression was positively correlated with a poor prognosis in LUAD patients, whereas overexpression of both CAR10 and SNAI was correlated with even worse clinical outcomes. |
| Pubmed ID | 30617305 |
| Year | 2019 |
| Title | Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis via miR-203/30/SNAI axis. |
External Links
| Links for CAR10 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |