Basic Information
| LncRNA/CircRNA Name | SSATX |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | RNA-seq, qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | HEMn-LP (normal human melanocytes, neonatal, lightly pigmented donor), A375 and A2058 (malignant human melanoma cells), and HEK 293T (human embryonic kidney cells). HEMn-LP cells (C-002-5C) |
| Expression Pattern | down-regulated |
| Function Description | SSATX is weakly expressed in melanoma cells. SSATX knockdown promoted the proliferation, migration, and invasion of human melanoma cells via the activation of the Wnt signaling pathway in a manner that was independent of SSAT1 expression. Based on our data, we propose that SSATX functions as a long non-coding RNA prior to its degradation in melanoma cells. |
| Pubmed ID | 31352009 |
| Year | 2019 |
| Title | Knockdown of SSATX, an alternative splicing variant of the SAT1 gene, promotes melanoma progression |
External Links
| Links for SSATX | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |