Basic Information
| LncRNA/CircRNA Name | SRA |
| Synonyms | SRA1, SRA, SRAP, STRAA1, pp7684 |
| Region | GRCh38_5:140537340-140558252 |
| Ensemble | ENSG00000213523 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, RNAi |
| Sample | cell lines (SiHa, CaSki and human cervical cancer cell lines) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA SRA knockdown inhibited cell proliferation, cell migration and tumor invasion in the cervical cancer cell lines. lncRNA SRA is a strong inducer and modulator of the expression of genes related to epithelial-mesenchymal transition and the NOTCH signaling pathway.lncRNA SRA is highly correlated with cancer progression and cervical cancer cell proliferation and migration. |
| Pubmed ID | 29039612 |
| Year | 2017 |
| Title | Long non-coding RNA, steroid receptor RNA activator (SRA), induces tumor proliferation and invasion through the NOTCH pathway in cervical cancer cell lines. |
External Links
| Links for SRA | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |