Basic Information
| LncRNA/CircRNA Name | CALML3-AS1 |
| Synonyms | NA |
| Region | GRCh38_10:5514244-5526246 |
| Ensemble | ENSG00000205488 |
| Refseq | NR_120496 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | CC cells (HeLa, CaSKi, SiHa, SW756, and C33A), Standard cervical epithelial cells (Ect1/E6E7), CC, non-cancerous tissues |
| Expression Pattern | up-regulated |
| Function Description | CALML3-AS1 was upregulated in CC tissues and this upregulation was associated with FIGO stage, histological grade, and reduced overall survival. Multivariate assays indicated that high CALML3-AS1 expression was an independent prognostic parameter indicating poorer clinical outcome for CC patients. Functional assays suggested that knockdown of CALML3-AS1 suppressed the proliferation, migration, and invasion of CC cells, and induced apoptosis. Mechanistic investigations revealed that inhibiting the expression of CALML3-AS1 decreased the levels of ?-catenin, cyclin D1, and c-myc via Western blot. |
| Pubmed ID | 31298313 |
| Year | 2019 |
| Title | Upregulation of lncRNA CALML3-AS1 promotes cell proliferation and metastasis in cervical cancer via activation of the Wnt/?-catenin pathway |
External Links
| Links for CALML3-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |