Basic Information
| LncRNA/CircRNA Name | SPRY4-IT1 |
| Synonyms | SPRY4-IT1, SPRIGHTLY |
| Region | NA |
| Ensemble | ENSG00000281881 |
| Refseq | NR_131221 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, Cell cycle assay, Cell apoptosis assay etc. |
| Sample | bladder cancer tissues, cell lines (EJ, UMUC3, T24T) |
| Expression Pattern | up-regulated |
| Function Description | SPRY4-IT1 knockdown induced inhibition of cell proliferation, cell migration and invasion ability,and caused promotion of apoptosis in bladder cancer both in vitro and in vivo.Mechanistically, knockdown of SPRY4-IT1 increased the expression of miR-101-3p and subsequently inhibited the expression of EZH2 at posttranscriptional level. Importantly, SPRY4-IT1 could directly interact with miR-101-3p and down-regulation of miR-101-3p efficiently reversed the suppression of EZH2 induced by SPRY4-IT1 shRNA. Thus, SPRY4-IT1 positively regulated the expression of EZH2 through sponging miR-101-3p, and played an oncogenic role in bladder cancer progression. |
| Pubmed ID | 27998761 |
| Year | 2017 |
| Title | LncRNA SPRY4-IT1 sponges miR-101-3p to promote proliferation and metastasis of bladder cancer cells through up-regulating EZH2. |
External Links
| Links for SPRY4-IT1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |