Basic Information
| LncRNA/CircRNA Name | SPRY4-IT1 |
| Synonyms | SPRY4-IT1, SPRIGHTLY |
| Region | NA |
| Ensemble | ENSG00000281881 |
| Refseq | NR_131221 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | qPCR etc. |
| Sample | pancreatic ductal adenocarcinoma tissues, cell lines (BxPC3, Capan-2, PANC1 and SW1990) |
| Expression Pattern | down-regulated |
| Function Description | SPRY4-IT1 was abnormally upregulated in PDAC tissues and cell lines,and this overexpression is closely associated poor clinical outcomes including advanced tumor stages, low differentiation grade and worse overall survival. Tumor stage and differentiation grade was closely correlated with SPRY4-IT1 expression. Additionally, decreased SPRY4-IT1 contributed to tumor suppressive effect through attenuating cell growth, clonogenic ability and facilitating apoptosis via Bcl-2/caspase-3 pathway in PANC1 and Capan-2 cells.Furthermore,the xenograft study confirmed the tumor proliferation-promoting role of SPRY4-IT1 in PANC1 cells. |
| Pubmed ID | 29551494 |
| Year | 2018 |
| Title | Upregulated long non-coding RNA SPRY4-IT1 predicts dismal prognosis forpancreatic ductal adenocarcinoma and regulates cell proliferation and apoptosis. |
External Links
| Links for SPRY4-IT1 | GenBank HGNC NONCODE |
| Links for pancreatic ductal adenocarcinoma | OMIM COSMIC |