Basic Information
| LncRNA/CircRNA Name | SPRY4-IT1 |
| Synonyms | SPRY4-IT1, SPRIGHTLY |
| Region | NA |
| Ensemble | ENSG00000281881 |
| Refseq | NR_131221 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | Microarray, qPCR, RNA-FISH etc. |
| Sample | cell lines (PPC1, 22Rv1, DU-145, LNCaP, PC3 etc.) |
| Expression Pattern | up-regulated |
| Function Description | AK024556 (SPRY4-IT1) was highly up-regulated in human prostate cancer cell line PC3 but not in LNCaP, and siRNA knockdown of SPRY4-IT1 in PC3 cells inhibited cell proliferation and invasion and increased cell apoptosis. |
| Pubmed ID | 25307116 |
| Year | 2014 |
| Title | Long noncoding RNAs as putative biomarkers for prostate cancer detection. |
External Links
| Links for SPRY4-IT1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |