Basic Information
| LncRNA/CircRNA Name | 91H |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
| Regulatory Mechanism | Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Information of Cancer
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, ChIP, Cell proliferation assay etc. |
| Sample | breast cancer tissues, cell lines (T47D, MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | Here, we observed that 91H, H19 and IGF2 are overexpressed in breast tumors. By using 91H-knockdown breast cancer cells, we demonstrated that 91H exerts oncogenic properties by promoting cell growth, migration and invasion as well as tumor growth in xenografted immunodeficient mouse model. Moreover, 91H-knockdown reduces the expression of H19 and IGF2 in breast cancer cells. By chromatin-immunoprecipitation and methylation studies, we found that 91H expression prevents histone and DNA methylation on the maternal allele at the H19/IGF2 locus. |
| Pubmed ID | 27780718 |
| Year | 2017 |
| Title | The long non-coding RNA 91H increases aggressive phenotype of breast cancer cells and up-regulates H19/IGF2 expression through epigenetic modifications. |
External Links
| Links for 91H | GenBank HGNC Noncode |
| Links for breast cancer | Omim Cosmic |