Basic Information
| LncRNA/CircRNA Name | SPINT1-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:40835808-40844387 |
| Ensemble | ENSG00000261183 |
| Refseq | NR_146466 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Dual luciferase reporter assay |
| Sample | colorectal cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | the expression of SPINT1-AS1 was increased (P<0.001, 3.771 vs 0.980) in CRC tissues,high SPINT1-AS1 expression was correlated with regional lymph node metastasis (P<0.001), distant metastasis (P<0.001), and shorter relapse-free survival (RFS) time (P<0.001), significant reduction of SPINT1-AS1 expression level (P=0.001) was observed in CRC serum exosomes after surgical resection. |
| Pubmed ID | 30022840 |
| Year | 2018 |
| Title | Increased Expression of Antisense lncRNA SPINT1-AS1 Predicts a Poor Prognosis in Colorectal Cancer and Is Negatively Correlated With Its Sense Transcript. |
External Links
| Links for SPINT1-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |