Basic Information
| LncRNA/CircRNA Name | CADM1-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, RNAi etc. |
| Sample | renal cancer tissues, cell lines (786-O, ACHN etc.) |
| Expression Pattern | down-regulated |
| Function Description | The results showed that CADM1-AS1 expression was down-regulated in tumor tissues in 64 patients with ccRCC compared with adjacent non-tumor tissues. Furthermore, the expression of CADM1-AS1 was positively correlated with the expression of mRNA CADM1 in ccRCC specimens. Decreased CADM1-AS1 expression was correlated with the progression of AJCC stage and worse survival of ccRCC patients. Also, multivariate analysis identified low CADM1-AS1 expression as an independent prognostic factor for ccRCC.CADM1-AS1 is a new tumor suppressor in ccRCC which regulates cell proliferation, apoptosis and migration via the expression pattern of CADM1-AS1/CADM1 mRNA gene pairs. |
| Pubmed ID | 25031695 |
| Year | 2014 |
| Title | Decreased expression of a novel lncRNA CADM1-AS1 is associated with poor prognosis in patients with clear cell renal cell carcinomas. |
External Links
| Links for CADM1-AS1 | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |