Basic Information
| LncRNA/CircRNA Name | SOX2-OT |
| Synonyms | NA |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cholangiocarcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | CCA tissues, CCA cell lines (HuH-28, QBC939, HuCCT1, CCLP1, RBE) and the intrahepatic biliary epithelial cell (HIBEC) |
| Expression Pattern | up-regulated |
| Function Description | The expression level of lncRNA SOX2-OT was significantly upregulated in cholangiocarcinoma tissues. Functional assays were further conducted to prove the oncogenic role of SOX2-OT on the proliferation and metastasis of cholangiocarcinoma cells. Furthermore, mechanism investigations manifested that transcription factor IRF4 upregulates SOX2-OT by promoting the transcriptional activity of SOX2- OT. SOX2-OT could positively regulate the nearby gene SOX2. SOX2-OT suppressed the nuclear transcription of PTEN, thereby activating PI3K/AKT signaling. |
| Pubmed ID | 30556855 |
| Year | 2018 |
| Title | IRF4-induced upregulation of lncRNA SOX2-OT promotes cell proliferation and metastasis in cholangiocarcinoma by regulating SOX2 and PI3K/AKT signaling |
External Links
| Links for SOX2-OT | GenBank HGNC NONCODE |
| Links for cholangiocarcinoma | OMIM COSMIC |