Basic Information
| LncRNA/CircRNA Name | SOX2-OT |
| Synonyms | NA |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung squamous cell carcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | plasma samples |
| Expression Pattern | up-regulated |
| Function Description | Exosomal SOX2-OT was significantly upregulated in LSCC patients .Moreover, exosomal SOX2-OT levels were significantly correlated with tumor size, TNM stage, and lymph node metastasis. Exosomal SOX2-OT levels were significantly decreased in the postoperative plasma of LSCC patients. |
| Pubmed ID | 30986097 |
| Year | 2019 |
| Title | Identification of an Exosomal Long Noncoding RNA SOX2-OT in Plasma as a Promising Biomarker for Lung Squamous Cell Carcinoma |
External Links
| Links for SOX2-OT | GenBank HGNC NONCODE |
| Links for lung squamous cell carcinoma | OMIM COSMIC |