Basic Information
| LncRNA/CircRNA Name | SOX2-OT |
| Synonyms | NA |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | qPCR |
| Sample | LSCC tissues,cell line |
| Expression Pattern | up-regulated |
| Function Description | In this study, we found that SOX2-OT expression was increased and negatively correlated with PTEN expression in LSCC tissues. |
| Pubmed ID | 30811870 |
| Year | 2019 |
| Title | Long noncoding RNA SOX2-OT facilitates laryngeal squamous cell carcinoma development by epigenetically inhibiting PTEN via methyltransferase EZH2. |
External Links
| Links for SOX2-OT | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell cancer | OMIM COSMIC |