Basic Information
| LncRNA/CircRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, RNAi |
| Sample | HCC tissue , adjacent normal tissue. human HCC cell lines (MHCC97H, SMMC-7721). normal liver cell line(LO2). |
| Expression Pattern | up-regulated |
| Function Description | Furthermore, it was demonstrated that knockdown of lncRNA Sox2ot downregulated the mRNA and protein expression of Twist1 and N-cadherin, but upregulated the E-cadherin expression levels in MHCC97H and SMCC-7721 cells. Thus, it was indicated that lncRNA Sox2ot may be a novel predictive biomarker and a potential therapeutic target for HCC. Association between lncRNA Sox2ot expression and vein invasion. Kaplan-Meier survival analysis and the log-rank test were performed to analyze the DFS and OS time of patients with HCC in higher and lower lncRNA Sox2ot expression groups. |
| Pubmed ID | 29963193 |
| Year | 2018 |
| Title | Upregulation of lncRNA Sox2ot indicates a poor prognosis for patients with hepatocellular carcinoma and promotes cell invasion. |
External Links
| Links for SOX2OT | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |