Basic Information
| LncRNA/CircRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi etc. |
| Sample | ESCC tissues, cell lines (NT2, U-87 MG etc.) |
| Expression Pattern | up-regulated |
| Function Description | Our data revealed a high level of SOX2OT expression in tumor samples of ESCC, compared to that of apparently normal marginal tissues obtained from the same patients. All together, our data provide a novel regulatory mechanism governing the key stem cell pluripotency genes, SOX2 and OCT4, mediated by the lncRNA SOX2OT. |
| Pubmed ID | 24105929 |
| Year | 2014 |
| Title | Two novel splice variants of SOX2OT, SOX2OT-S1, and SOX2OT-S2 are coupregulated with SOX2 and OCT4 in esophageal squamous cell carcinoma. |
External Links
| Links for SOX2OT | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |