Basic Information
| LncRNA/CircRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Cell proliferation assay, Cell migration and invasion assay etc. |
| Sample | gastric cancer tissues, cell lines (SGC-7901, AGS, GES-1) |
| Expression Pattern | up-regulated |
| Function Description | The expression of Sox2ot was overexpressed in gastric cancer tissues and cell lines. High levels of Sox2ot were correlated with malignant status and poor prognosis. Silencing Sox2ot expression effectively inhibited gastric cancer cell growth and motility in vitro. |
| Pubmed ID | 27904704 |
| Year | 2016 |
| Title | LncRNA Sox2ot overexpression serves as a poor prognostic biomarker in gastric cancer. |
External Links
| Links for SOX2OT | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |