Basic Information
| LncRNA/CircRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR etc. |
| Sample | cell lines (HeLa, MCF7, HepG2, U-87 MG and NT2) |
| Expression Pattern | up-regulated |
| Function Description | We screened the expression level of two novel transcripts, SOX2OT-7 and SOX2OT-8 in five selected human cancer cell lines (HeLa, MCF7, HepG2, U-87 MG and NT2) by Real time RT-PCR. To facilitate the comparison of cell lines, HeLa cell line (which showed the least expression values) was considered as calibrator. Unexpectedly, all tested cancer cell lines, especially NT2 showed high levels of SOX2OT-7 and SOX2OT-8 expressions; except Mcf-7 which expresses the minimum level of SOX2OT-8. |
| Pubmed ID | 26703382 |
| Year | 2016 |
| Title | Identification of new SOX2OT transcript variants highly expressed in human cancer cell lines and down regulated in stem cell differentiation. |
External Links
| Links for SOX2OT | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |