Basic Information
| LncRNA/CircRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | CRC tissues, CRC cell lines |
| Expression Pattern | up-regulated |
| Function Description | We found that lncRNA Sox2ot was increased in CRC tissues and cell lines. High expression of Sox2ot was associated with the progression of CRC patients. Decreased Sox2ot expression inhibited the proliferation capacity and caused cell cycle arrested in G0/G1 phase in CRC cells. The key cell cycle regulators Cyclin B1 and Cdc 25C were consistently downregulated by knockdown of Sox2ot. Furthermore, knockdown of Sox2ot suppressed cell migration and invasion and decreased the expression of mesenchymal protein N-cadherin, while it increased the expression of epithelial protein E-cadherin in CRC cells. |
| Pubmed ID | 27353770 |
| Year | 2016 |
| Title | Enhanced expression of long non-coding RNA Sox2ot promoted cell proliferation and motility in colorectal cancer. |
External Links
| Links for SOX2OT | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |