Basic Information
| LncRNA/CircRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown, Luciferase reporter assay etc. |
| Sample | cell lines (U87, U251) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of SOX2OT significantly increased the expression of miR-194-5p and miR-122 in GSCs.SOX2OT bound to both miR-194-5p and miR-122. SOX3 and TDGF-1 were up-regulated in human glioma tissues and GSCs. Knockdown of SOX3 inhibited the proliferation, migration and invasion of GSCs, promoted GSCs apoptosis, and decreased TDGF-1 mRNA and protein expression through direct binding to the TDGF-1 promoter. Over-expression of miR-194-5p and miR-122 decreased the mRNA and protein expression of SOX3 by targeting its 3??TR. Furthermore, SOX3 knockdown also inhibited the SOX2OT expression through direct binding to the SOX2OT promoter and formed a positive feedback loop. |
| Pubmed ID | 29132362 |
| Year | 2017 |
| Title | Knockdown of SOX2OT inhibits the malignant biological behaviors of glioblastoma stem cells via up-regulating the expression of miR-194-5p and miR-122 |
External Links
| Links for SOX2OT | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |