Basic Information
| LncRNA/CircRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | Lung cancer tissues and cell lines (A549, H1299, NCI-H460, and HCC-827) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of SOX2OT inhibited the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) process in NSCLC cells. Moreover, we explored the regulatory mechanism of SOX2OT and found that SOX2OT directly bound microRNA 132 (miR-132) in NSCLC cells. Importantly, miR-132 inhibition partially reversed the SOX2OT knockdown-mediated inhibitory effect on cell proliferation, migration, invasion, and EMT process. We also found that SOX2OT could regulate zinc finger E-box-binding homeobox 2 (a target of miR-132) expression, which played crucial roles in tumor cell proliferation and invasion. |
| Pubmed ID | 30214232 |
| Year | 2018 |
| Title | Long Noncoding RNA Sox2 Overlapping Transcript (SOX2OT) Promotes Non-Small-Cell Lung Cancer Migration and Invasion via Sponging microRNA 132 (miR-132) |
External Links
| Links for SOX2OT | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |